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Pragmatic post-marketing studies using flexible dosing schedules allow clinicians to better judge the utility of the new drug in a wider population of patients with epilepsy and decide the most appropriate dosing schedules.
Further comparative studies are required to determine the most appropriate dosing schedule of intravitreal bevacizumab injections for BRVO patients with ME.
We included the full range of observed dosing in our analysis based on the assumption that, in selecting medications, physicians also use what they believe is the most appropriate dosing and titration for that medication.
Studies have been performed to test less intensive dose regimens, including twice weekly dosing [ 17, 37], and their results were encouraging, but additional trials are needed to identify the most appropriate dosing regimen [ 10].
Taking these into consideration, the level two regimen (oral UFT 400 mg m−2 per day for 14 consecutive days+GEM 900 mg m−2 on days 8 and 15) appears to be the most appropriate dosing option.
Developmental physiological changes within the first few weeks of birth have the potential to markedly impact drug disposition, making selection of the most appropriate dosing regimen particularly difficult [1 4].
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Sanofi, the manufacturer of Ambien and Ambien CR, said in a statement that people taking zolpidem "should always talk to their doctor about the most appropriate dose," and that the label "provides important information" to determine what that is.
This study was not designed to identify the optimal strategy or most appropriate dose of urea therapy.
This study also aims to determine the effects of benazeprilat on serum angiotensin converting enzyme (ACE), selecting the most appropriate dose that suppresses ACE activity.
In gene transfer trials, it is essential that meaningful correlative endpoints are employed in order to correlate the employed doses with biological effect and select the most appropriate dose for phase II setting.
This concentration was based on a pilot study to determine the relationship between prawn mortality and the challenge dose (107, 106, 105, 104 and 103 CFU/ml) and the most appropriate dose was chosen based on the occurrence of 50% mortality of prawns over a 2-week period.
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