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Such preclinical data must then help drive the appropriate early phase I combination studies to be evaluated - studies which if well tolerated and active, as determined by relevant pharmacodynamic endpoints, need to rapidly be tested in phase II studies utilising enrichment strategies to select for the most appropriate breast cancer phenotypes.
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Due to the lack of evidence-based data on the most appropriate protocols for breast surveillance of BC patients, published practice guidelines give somewhat conflicting information.
The uncertainties surrounding the most appropriate treatment of breast cancer in BRCA1 and BRCA2 gene carriers is of critical importance and must be resolved in order that clinicians can better tailor treatment in hereditary breast cancer.
However, it is critical to consider both clustering and pathway activation and to combine these methods to choose the most appropriate model to mimic human breast cancer.
Recent guidelines from the Society of Nuclear Medicine have listed the most appropriate use criteria for PET/CT in breast oncology [13].
The most appropriate level of axillary dissection for breast cancer remains unclear.
BSOP are most appropriate when resecting 20%to50%0% of the breast volume [ 4], when the likelihood of major deformity escalates [ 2].
This article hypothesizes that Cox proportional hazards models are not the most appropriate for studying the evolution of breast cancer-related events occurring in a patient.
In conclusion, the results of the present study suggest that evaluation of cyclin E expression levels might help to select the most appropriate treatment for cancer patients, mainly breast cancer patients, by reserving anthracycline treatment to patients whose tumours do not overexpress this molecule.
A critical choice facing breast cancer patients is which surgical treatment – mastectomy or breast conserving surgery (BCS) – is most appropriate.
Accurate prognostication is essential when selecting the most appropriate adjuvant therapy following surgery for early breast cancer.
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