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Ideally, each sequence should be annotated and validated by a human expert, who has the knowledge to infer the most appropriate annotation.
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A discussion follows where the GOC comes to a consensus about the most appropriate annotations for that article and in the process educates its staff.
Computational integration of diverse evidence can help in assigning function, and ideally these inferences can reflect the shades of gray in our current knowledge, as opposed to the "black or white" annotation that is most appropriate for archival annotation.
We further utilized eQTL replication to determine the most appropriate model for gene annotation.
These cases will be subject to further analyses as for most of them no appropriate annotation could be found and thus no conclusion could be drawn about their biological significance.
Many questions arise about what kind of corpus is best suited to the research questions under consideration, as well as what kind of annotation is most appropriate.
This table was used to determine the fields that would be most appropriate to probe for metadata annotation using the structured word lists (Table 2).
One of the most appropriate ways of defining the accuracy of assembly and annotation of metagenomic data are to use in silico simulated data from fragmented genomes [ 42] or actual fragmented genomic DNA from known organisms [ 43].
It is important to be aware of alternate annotation information in order to choose the most appropriate data set for further analysis or experimental design.
Contrary to GO annotation, MapMan assigns a gene to the most appropriate functional category (BIN) rather than sorting it into multiple BINs.
It is also possible that annotation of information from abstracts is not the most appropriate task because the bulk of the curation effort is in scrutinizing the full paper.
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CEO of Professional Science Editing for Scientists @ prosciediting.com