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This could have been the result of CtxB not being the most appropriate adjuvant for oral vaccination with Pfs25.
Accurate prognostication is essential when selecting the most appropriate adjuvant therapy following surgery for early breast cancer.
Selecting patients with primary breast cancer for the most appropriate adjuvant systemic treatment is of great importance.
Overall, 70% of samples tested provided information on chemotherapy resistance, suggesting that selection of the most appropriate adjuvant therapy could be guided by in vitro results.
Reliable prognostic and predictive markers are needed to guide the selection of the most appropriate adjuvant therapies for individual patients with breast cancer.
Each of these factors may be an important consideration in assessing the most appropriate adjuvant therapy with the least toxicity for an individual woman.
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The current assessment of the histological and clinical characteristics of tumours fails to identify patients most appropriate for adjuvant systemic therapy.
Preoperative identification of patients with adverse prognostic features may allow targeting of such patients for the most appropriate preoperative adjuvant therapy, assist in surgical planning and serve as an accurate baseline study from which to assess the success of different treatment strategies.
There is increasing interest in the identification of prognostic molecular markers, which may be used to select the most appropriate patients for adjuvant chemotherapy or to identify colorectal cancer patients at increased risk of disease progression.
Since hypoxia decreases the sensitivity of tissues to radiation and thus lessens the efficacy of radiotherapy, PET scanning with FMISO may provide useful information in selecting the most appropriate form of adjuvant therapy for bone and soft tissue tumours [ 32].
I also think it is premature to use these trials to make conclusions about the most appropriate duration of adjuvant treatment with an aromatase inhibitor, as duration of AI treatment ab initio is clearly different from switching to an AI after several years of tamoxifen treatment.
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