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As the above results suggested that any treatment-by-sequence of enrollment interaction might be most apparent in lower-risk patients, the entire ADDRESS population was compared with the lower-risk population in PROWESS as defined by an APACHE II score of less than 25.
The results confirm that the protective effect of a defunctioning stoma is probably most apparent in high-risk patients, while the additional benefit for the rest of the population is limited or even non-existent.
Recent studies suggest that risk is most apparent in females treated with cranial radiation at a younger age.
This higher risk is most apparent in women with a strong personal or family history of troublesome headaches, particularly migraine [67].
This effect was most apparent among women at high risk for HSV-2 infection.
Analysis of this effect on outcomes suggests that it is most apparent in patients at lower risk of death.
For acute myocardial infarction and coronary heart disease, the increased risk was most apparent in the 55-year to 65-year age groups (figure 2F,G).
Our data also suggest that the potential protective effect of vigorous activity on postmenopausal breast cancer risk is most apparent among lean or normal weight rather than overweight women.
Our finding that most cryptococcosis patients in China had no apparent risk factor is in stark contrast with reports from other countries.
Furthermore, analysis of joint effects with occupational sitting time suggests that the reduction in risk with exercise was most apparent among post-menopausal women who held sedentary jobs.
In the meantime, however, it is the political risks of the endeavor that are most apparent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com