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Naturally there are teething problems: we are understaffed and feeding the notes online is gradual, partly reliant on that most analogue of systems, the postal service.
Can this most analogue of toys – dreamed up by an entrepreneurial carpenter in Billund in 1932 – really teach us how to build better cities? Or is this just a smart extension of the Lego brand, to persuade well-heeled parents that an expensive Lego City Monster Truck is a serious educational toy?
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Most analogues presented low agonistic activity when compared to AII in the different bioassays tested.
Most analogues exhibited stronger protective effects than the positive control ningnanmycin.
The aphicidal bioassay results showed that most analogues exhibited considerable aphicidal activity against Myzus persicae.
Most analogues bearing 3-trizolylmethyl showed good to moderate antibacterial activities.
Antiviral testing showed that most analogues of 4 inhibited HIV-1 in the low nanomolar to submicromolar range, without cytotoxicity at concentrations up to 100 μM.
In the topoisomerase inhibition test, most analogues in group III and IV except compound 11 exhibited more efficient topoisomerase I inhibitory activity than camptothecin at 20 μM.
Most analogues exhibited higher antiproliferative activities against human acute myeloid leukemia cell U937 than the other two human lung cancer cell lines.
Preliminary bioassays showed most analogues exhibited good insecticidal activities at 100 mg/L, and compound 1d and 2a were highly potent even at 10 mg/L.
The racemates of most analogues were conveniently synthesized via arylations of benzylacetonitriles with halopyridines or alkylations with haloalkanes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com