Melanoma is the most aggressive form of skin cancer.
Malignant melanomas represent the most aggressive form of skin cancer.
The histological variants of ILC are indistinguishable from the classic type by imaging alone, even for the pleomorphic variant, which is the most aggressive ILC variant.
The TF expression has been previously reported in endometrial endometrioid adenocarcinoma cell lines (i.e., the most common and less aggressive variant of human endometrial cancer; Kato et al, 2005, 2008).
Our research group has recently examined Her2/neu expression, gene amplification, and its association with outcome in USC, the most aggressive and chemotherapy-resistant variant of endometrial carcinoma (Santin et al, 2002, 2005a, 2005b, 2005c, 2008; El-Sahwi et al, 2010).
The extremely rare S52P TTR variant is the least stable TTR variant and causes the most aggressive phenotype of hereditary systemic TTR amyloidosis (Mangione et al, 2014).
The large-cell-anaplastic variant is clinically the most aggressive subtype, and represents between 4 and 25% of all medulloblastomas cases (Leonard et al, 2001; Eberhart et al, 2002).
In micropapillary tumours only positive MTUS1 expression was found, which, in this entity, cannot be responsible for decreased malignancy, as this variant is one of the most aggressive tumour types found in the bladder.
Among nonpolypoid variants, depressed subtypes have the most aggressive behavior and represent the main lesions of de novo pathway [ 2- 7].
