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Recently, we demonstrated that miR-210 was overexpressed in the most aggressive stages in human non-small cell lung carcinomas (NSCLCs) and correlated with a hypoxic signature.
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Moreover, in gastric cancer, DNA methylation from the pre-malignant till the most aggressive stage of cancer can be defined.
Our work here focused on studying the molecular mechanisms involved in the enhanced apoptosis resistance of PCa cells in their transition to the most aggressive hormone-refractory stage.
He followed this on stage 17 with an identical display of aggressive prowess and took the honours for the most aggressive rider on the stage but missed out on a win.
On the other side of the chart– literally and figuratively– are Kleiner Perkins and Andreessen Horowitz, the two most aggressive at the late stage game, but utterly different stories are behind the common strategy.
There is also a white jersey for the Tour's quickest young rider, a team prize and an award for the most aggressive rider on each stage, while the man who is last overall is called the Lanterne Rouge.
while at later stages, the most aggressive subclone persists, being sensitive if σ < c (n(t) ∝ e s (N +1) t ) and resistant otherwise (n(t) ∝ e(s (N + 1) − c ) t ).
In a swell bit of turnabout, he was named the stage's most aggressive rider.
For now, though, the only people standing in the way of the Lendu fighters are overstretched United Nations peacekeeping forces, who have recently staged their most aggressive raids in Ituri since the mission began in 1999.
Not surprisingly, start-ups tend to be the most aggressive - especially in their early stages.
There is an urgent need for new predictive markers that distinguish the most aggressive prostate cancers at an early stage.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com