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Hypoxic cancer cells are more resistant to radiotherapy and represent the most aggressive fraction of a tumour.
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Therefore this strategy allows us to concentrate Chk1/Aurora kinase A inhibition in hypoxic cells, targeting the most aggressive tumor fraction, while protecting normal tissue.
The power of exon-based expression analyses lies in the identification of alternatively used transcripts in tumours, which can provide new insights into the aberrant circuits of the most aggressive tumour fraction, harbouring a plethora of options for therapeutic interventions.
At the second stage, a separate portion of the sample is decalcified with 0.1 N H2SO4 to estimate FA1a (the most mobile "aggressive" fraction of FA) in the filtrate.
This novel approach targets the most aggressive and therapy-resistant tumor fraction while protecting normal tissue from therapy-induced genomic instability.
With a median survival of less than a year, neuroendocrine prostate cancer (NEPC) represents the most aggressive prostate malignancy and only a small fraction of NEPC patients benefit from current treatments [ 1].
Despite being one of the world's most aggressive killers globally (an estimated 30 million people have it today), when compared with other chronic diseases, HIV/AIDS receives a fraction of the financial support for research or prevention efforts.
America's most aggressive chief executive?
Among the most aggressive C.D.O.
Zurich, has been among the most aggressive.
The most aggressive apes of all were the bonobos.
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