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Extent of tumour spread, obtained from the CCR, summarises the most aggressive extent of the disease based on diagnostic and therapeutic evidence within four months of diagnosis [ 20].
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Because of tumor heterogeneity, a biopsy may not adequately sample the most aggressive area of the tumor or sufficiently gauge the extent of genomic deviations within it, making therapeutic decision-making more challenging.
Reduced p27 expression was associated with the most aggressive forms of prostate cancer and poor survival [31], [32], to such an extent that p27 was proposed as a biomarker for this tumor [32].
Differential expression of MMP-9 reflects the extent of cellular differentiation in breast cancer cells and is closely related to the most aggressive subtypes of breast cancer.
America's most aggressive chief executive?
Among the most aggressive C.D.O.
Zurich, has been among the most aggressive.
The most aggressive apes of all were the bonobos.
"Bob is the most aggressive in his industry," he says.
Qatar is among the most aggressive investors in the region.
Germany is the country most aggressive in protecting individual privacy.
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