Sentence examples for most aggressive clone from inspiring English sources

When two or more mutator mutations are required to generate the mutator phenotype [as would be the case for recessive mismatch repair (MMR) genes (Markowitz and Bertagnolli 2009)], the rate at which mutator genes drift to dominance within the most aggressive clone is much slower than the rate at which the most aggressive clone acquires the next driver mutation.

To further support this conclusion, we note that the correlation between the crossover time and the fitness of the most aggressive clone is strong (−0.66) in the high α regime, while it is negligible (−0.03) in the low α regime.

The clone with the most driver mutations (termed the most aggressive clone) accrued a significant number of driver mutations prior to developing a mutator phenotype; when additional driver mutations caused large increases in fitness, the number of driver mutations accrued prior to a mutator phenotype increased (Fig. 5C).

As the probability of a cell acquiring a deleterious mutation was comparable to that of the cell acquiring an advantageous mutation, negative clonal selection impeded the growth of only rare cells within the most aggressive clone, and so failed to impede tumour growth.

In the case of strong selection for additional driver mutations, the growth of the most aggressive clone (the clone with the most driver mutations) is very rapid, so that many cells that are 'susceptible' to acquiring the next driver mutation are rapidly produced.

Our data show that few mutations (8% to 22%) were shared between all three subpopulations, and that the most aggressive clones comprised a minority of the tumor mass.

In this way, mutator mutations are effectively removed from the tumour population as a result of their being outcompeted by the most aggressive clones.

Mutator mutations are assumed to be selectively neutral in the model; mutator mutations therefore accrue only through genetic drift or by hitchhiking on the most aggressive clones.

Unless deleterious mutations were very common, they did little to impede the progression of the most aggressive clones, supporting Beckman and Loeb's previous conclusion (Beckman and Loeb 2005).

Wipe out one subtype of a cancer — the clone that seems most aggressive, say, or the one that's most prevalent in a biopsy — and you may have slowed the disease or thinned it out.

The integrated shRNAs present in the most aggressive tumors were then amplified by polymerase chain reaction and cloned for subsequent validation.