Among all the ROS produced, OH radicals are among the most aggressive forms implied in cellular oxidative stress [1] [2].
Glioblastoma, the most common and most aggressive form, is characterized by marked cellular heterogeneity, high proliferative activity, aberrant microvascular proliferation, presence of necrosis and highly invasive growth (Riemenschneider & Reifenberger, 2009).
The most aggressive cancers have developed a further program of cellular plasticity that is very useful to adapt to particular environmental changes, i.e. the mesenchymal amoeboid transition (MAT).
The association of CD44 with the most aggressive subtype of disease is consistent with the well-established cellular functions of CD44 in promoting cell invasion and cell adhesion in vitro, and the capacity for CD44 to increase spontaneous metastasis of breast cancer cells in vivo [7,8; McFarlane S, Coulter J, Waugh DJJ, unpublished observations].
The RIT approach is made possible by the fact that most aggressive tumours contain large numbers of dead and dying cells with compromised cellular membranes that permit antibody to access intracellular viral antigens.
Differential expression of MMP-9 reflects the extent of cellular differentiation in breast cancer cells and is closely related to the most aggressive subtypes of breast cancer.
Yahoo!, the most aggressive content player in the wireless arena, has so far avoided charging subscription fees for its cellular content.
(See: "Gaming The System").. T-Mobile for instance is expected to be among the most aggressive bidders during the upcoming auction as it has the weakest position amongst the major domestic cellular carriers.
America's most aggressive chief executive?
Among the most aggressive C.D.O.
