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Ageing affects most tissues and physiologic functions, and one of the most affected organs is the skeletal muscle.
The most affected organs were the mantle, digestive gland and gonad.
The complexity of CFTR maturation and turnover requires the use of cellular models that closely recapitulate the specific properties of the clinically most affected organs.
Furthermore, the complexity of the mutant CFTR maturation and turnover kinetics requires the use of advanced cellular models that closely recapitulate the properties of the most affected organs (lung, bile duct, pancreas, and intestine).
The most affected organs in males were the liver, hepatodigestive tract, and kidneys(Table 2; Figure 1A,B,C,D,E,F,G,H,I). Liver abnormalities such as hepatic congestions andmacroscopic and microscopic necrotic foci were 2.5 to 5.5 times more frequent in alltreatments than in control groups, where only two rats out of ten were affected withone abnormality each.
One of the most affected organs in SLE is the kidney.
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Urinary endometriosis accounts for 1% of all endometriosis where the bladder is the most affected organ.
In our series, the stomach was the most affected organ.
The second most affected organ in females was the pituitary gland, in general aroundtwo times more than in controls for most treatments (Table 2; Figure 1J,K,L,M).
Following data reported in the paper by Rao et al., the third most affected organ is the eye, with a frequency of involvement ranging from 10 to 60%[11]1].
At necropsy, the most affected organ was the lung.
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