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Whereas some investigators have found that adjuvant use of HDI for non-metastatic melanoma is cost-effective, with cost-utility ratios comparable to those for other cancer interventions, 11 others have suggested that it may be cost-effective in only the most advanced adjuvant sub-stages.
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The most advanced TLR4 agonist is an adjuvant derived from the LPS of Salmonella minnesota which is known as Monophosphoryl Lipid A (MPL®).
TLR ligands are used in modern vaccine adjuvants, TLR4 ligand-based adjuvants are the most advanced in commercial vaccines.
Despite this, the strategy to codeliver RTS,S with more clinically advanced adjuvant systems, AS02 and AS01, has led to the most promising malaria vaccine results up to date [ 2, 3].
Venezuela's are the most advanced.
Calls L-1011 today's most advanced airliner.
"It is the most advanced democracy, dummy.
Most advanced?
Making advanced chips involves some of the most advanced technology in the world.
"I think we are the most advanced.
Our most advanced problems require our most refined idealistic powers.
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