Sentence examples for most active variant from inspiring English sources

The most active variant isolated, with TLSATP substituted for FLEAI, inhibited thrombin 2.9-fold more rapidly than API M358R.

Here the I117A mutant of human MATI was identified as the most active variant for biochemical production of SAM analogues from diverse SAAMs.

The most active variant, identified after only one round of diversification and screening of only 10,000 wells, is approximately 400-fold more active on glucose than is the wild-type enzyme.

Embryos were injected with a helper plasmid encoding the most active variant, Int*-KEE.

Our most active variant Q25R, completely suppressed aldolase aggregation at this ratio so it was in addition further diluted and measured at a Spy: aldolase ratio of 0.1.

The first set of machine learning-based designs significantly outperformed those based on a manual "expert" analysis in set 1. Thirteen of the twenty variants in set 2 were more active than wild-type proteinase K, with 8 more active than the most active variant from set 1. Encouraged by this result we performed a second cycle of machine learning.

The main objectives were therefore to set up a complete strategy for creation and automated screening of rCelStrep evolved direct mutants and to apply it to generate and screen a library of 10,000 random mutants to select the most active variants.

These substitutions were incorporated into every variant in round 3 and are present in the most active variants.

Strong positive: the substitution was selected by all third round design methods and are present in the most active variants.

To avoid bias resulting from varying levels of protein expression, the most active variants were purified and analytical-scale biotransformations were performed using normalized protein concentrations (see Figure S4).

Instead, the most-active variants keep their aromatic residues exposed to the solvent.