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An adaptive selection of vaccine administration schedules may have identified the most active treatment regimen for phase 3 confirmatory trials.
Therefore, assessment of EGFR mutational status is mandatory in order to choose the most active treatment in NSCLC patients.
Age and comorbidity may hamper the use of the most active treatment regimen, such as high dose cytarabine and autologous stem cell transplantation.
Although we only had information on treatments received within a year of diagnosis, most active treatment for the primary tumour would be offered within this time.
High-dose chemotherapy with alkylating agents and stem-cell support is the most active treatment in patients with metastatic breast cancer.
Vinorelbine plus trastuzumab is one of the most active treatment regimens for patients with HER 2-positive metastatic breast cancer and demonstrates a very favourable safety profile allowing prolonged treatment with long-term survival.
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For the most active treatments the mechanism of action was assessed through flow cytometry.
In clinical trials, the docetaxel/cisplatin combination is one of the most active treatments of advanced NSCLC (Rodriguez et al, 2001).
Many studies showed that most active treatments reduced the size of lymphatic limbs, although extensive study heterogeneity in areas such as length of follow-up, treatment protocols, comparators, and outcome measures prevented us from assessing whether any one treatment was superior.
The survival results compares favourably with those reported on for other active regimens, ranking the combination of cisplatin and vinorelbine among the most active cytotoxic treatments for MPM reported to date (Table 5).
The taxanes (paclitaxel and docetaxel) are among the most active drugs for treatment of breast cancer and are an important component of treatment in the neoadjuvant, adjuvant, and metastatic settings.
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