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Subgroup analysis showed a significantly higher RR for gallbladder carcinoma (GBC) compared with cholangiocarcinoma (CC), but longer OS for cholangiocarcinoma, and GP was suggested as the most active regimen in BTC.
The most active regimen, lysostaphin given three times daily, produced sterile vegetations in 10 of 11 treated rabbits, while the number of bacteria in the untreated controls increased to the level of 8.5 × 10 CFU/g.
We report that an anthracycline-based regimen was administered in 83.5% of patients (anthracycline without taxane in 59.1% and anthracycline with taxane in 24.4%) while CMF-like anthracycline-regimens (without or with taxane) highlights that if the decision was to administer chemotherapy, the most active regimen was selected, also in small breast cancers.
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When it was decided to administer adjuvant chemotherapy, the most active regimens, anthracycline-based, were selected.
Gemcitabine plus cisplatin (GC) is one of the most active regimens in the treatment for stage IIIB/IV NSCLC patients.
Cisplatin and intravenous vinorelbine is a highly active regimen in MPM with a response rate and survival comparable to the most active regimens so far reported.
We conclude from our data that high-dose EPI, contrary to previous negative studies using lower doses of EPI, ranks amongst the most active regimens against advanced NSCLC.
First, in an attempt to treat distant micrometastases, we used a two-drug combination of cisplatin plus docetaxel– one of the most active regimens for advanced NSCLC (Schiller et al, 2002).
The feasibility and tolerability of this doublet is already very well known from its use in non-small cell lung cancer (NSCLC) in which it is among the most active regimens.
Gemcitabine cisplatin chemotherapy is considered one of the most active regimens for advanced NSCLC, with an overall response rate (ORR) of 22 38% and median survival of 8.1 9.8 months in phase III trials (Crinò et al, 1999; Scagliotti et al, 2002; Schiller et al, 2002).
In contrast to other LGG therapies, our recent experience, showed that lower doses of cisplatin (25 mg/m2/dand and etoposide (100 mg/m2/day) is probably one of the most active regimens with reduced neurotoxicity and myelotoxicity to treat children with DS related to low-grade optic-hypothalamic glioma [ 20].
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