Sentence examples for most active metabolite from inspiring English sources

Calcitriol, the most active metabolite of vitamin D, elicits significant antiproliferative activity in breast cancer cells by several vitamin D receptor (VDR) mediated mechanisms including regulation of growth arrest, cell differentiation, migration, invasion and apoptosis [ 12- 14].

All-trans-retinoic acid (ATRA), the biologically most active metabolite of vitamin A, plays a major role in the regulation of cellular differentiation and proliferation, and it is also an important pharmacological agent particularly used in the treatment of cancer, skin, neurodegenerative and autoimmune diseases.

Considering that the 5 was the most active metabolite, the effects of this compound was investigated on LPS-induced PGE2 production in RAW 264.7 cells using ELISA method with slight modification.

Because both fluoxetine and norfluoxetine (the most active metabolite of fluoxetine [63] levels were below the detection threshold at the time of behavioral testing we do not expect that the differential norfluoxetine/fluoxetine ratio's in adult and adolescent rats affected the behavioral outcomes.

In particular, inherited single nucleotide polymorphisms (SNPs) in CYP2D6 result in poor conversion of the relatively inactive parent compound, tamoxifen, into its most active metabolite, endoxifen [ 21- 23].

It is well noted that ATRA (all- trans retinoic acid), the most active metabolite of vitamin A is required for the appropriate differentiation of normal human prostate epithelial cells (Sonneveld et al, 1998).

CYP2D6 is predominantly responsible for the 4-hydroxylation of tamoxifen leading to its most active metabolites, 4-hydroxytamoxifen and endoxifen (Dehal and Kupfer, 1997).

At a general evaluation of the results, it is unclear why thiamine is not as effective in preventing cisplatin-related hepatotoxicity as TPP, its most important active metabolite.

The most therapeutically active metabolites are N-desmethyl-4-hydroxytamoxifen (endoxifen) and 4-hydroxytamoxifen, being 30- to 100-fold more potent than tamoxifen itself.

We recently demonstrated that prostaglandin E2 (PGE2), the most active pro-inflammatory metabolite of COX-2, induces phosphorylation of Akt at Ser473 and GSK-3β at Ser9, a known downstream target of pAkt [ 9].

The biologically most active vitamin D metabolite 1,25(OH)2 vitamin D (calcitriol) is known to affect immune and airway functions, which is the basis of the hypothesis that vitamin D status may be directly linked to asthma and allergic diseases [ 2, 3].