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All active drugs, including EPI, should be considered to design the most active combination.
Imatinib + γ-irradiation was also the most active combination against primary colony-forming CML cells.
This supports the administration of irinotecan at 7 HALO and oxaliplatin at 15 HALO as the best tolerated and the most active combination schedule.
However, there was some heterogeneity, though in most (20/24) tumors cisplatin + gemcitabine was the most active combination, in 4/24 tumors docetaxel + gemcitabine was the most active.
The most active combination overall was SN-38 for 3 days, followed by 1 day without drug treatment, and then etoposide for a further 3 days.
The most active combination overall, as evaluated by induction of apoptosis, was SN-38 for 3 days, followed by 1 day drug free and then etoposide for a further 3 days in all cell lines.
Similar(52)
MIC is clearly a well tolerated regime and among the most active combinations in non-small cell lung cancer.
Among the most active combinations was that of topotecan plus 5-FU in breast cancer, which demonstrated synergy in 57% of specimens.
Although the haloduracin peptides are most active in combination, at much higher concentrations both Halα and Halβ displayed independent activity against the highly susceptible L. lactis HP strain.
Some of the most active older combinations have contained doxorubicin or cisplatin (Sporn and Greenberg, 1993; Parnis et al, 2000).
The present study demonstrated that Raltitrexed when used as second-line treatment after prior lrinotecan+5-FU+LV in ACC has limited activity, a 12% RR, and provides clinical benefit in 32% of these patients pre-treated with the most active first-line combination of lrinotecan+5-FU+LV lrinotecan+5-FU+LV
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