In situ UV vis micro-spectroscopy reveals the formation of 400 nm and 580 nm absorption bands, which are ascribed to poly-alkylated benzene (PAB) carbocations, the most active HCP species and poly aromatics (PA) the deactivating species, respectively.
Compound 2b bearing a hydrophobic aromatic tie was the most active derivative against all bacteria studied with MIC values ranging from 0.098 to 0.78 μg/mL.
Each fraction contains different types of contaminants depending on their polarity, planarity and the of aromatic system, and the most active ones have been prioritised for further analysis aimed to identification and quantification of key pollutants |From [36], with permission).
Thus, efficient channel formation depended upon having hydrophobic residues at these positions, aromatic residues being the most active.
The most active compounds were the sulphonepiperazines, particularly those with an aromatic substitution attached to the piperazine moiety.
The human enzyme CYP1A1 is the most active among the CYPs in metabolizing procarcinogens, particularly, the polycyclic aromatic hydrocarbons (PAHs), into highly reactive intermediates [ 30].
The two HY-AR features are properly mapped on the aromatic rings of the xanthone moiety of the most active AChEI compound 1).
The most active compounds were non-symmetrical furan-amidines with meta- and para-nitro substitution on the aromatic ring, with IC50 values of 15 nM.
We find that the most active substrates presented here, those having an N-terminal Arg to the acetylated lysine and with basic and aromatic residues favored at the C-terminal position relative to the acetylated lysine, do not mimic many of the known natural substrates, including histones.
The two most active compounds (6, 14) both in the parasite amastigotes and in the enzyme contain the nitro group in para position of the aromatic ring.
