Sentence examples for most active analogs from inspiring English sources

Therefore, we have used an in vitro plaque assay to screen a limited proprietary library of small organic compounds and identified highly bioactive leads, with the most active analogs showing activity in low picomolar range.

Furthermore, molecular docking study was performed to help understand binding interactions of the most active analogs with α-glucosidase enzyme.

The most active analogs were evaluated for iv and oral pharmacokinetic properties via cassette dosing in rat and in mice pharmacokinetic models.

However, in vivo studies on 15a and 16a, the most active analogs, are warranted to investigate the exact mechanisms of action responsible for their cytotoxicity.

Follow-up kinetic assays were conducted on the five most active analogs, the sterically true phosphonate (5) and its N-methyl (27) and N,N-dimethyl (28) congeners, as well as the malonyl ether (13) and the phosphoramide (22).

The most active analog 3d inhibited interleukin-5 activity with an IC50 of 17.5 μM.

The most active analog 20 showed potent in vitro anticancer activity against the MDA-MB-231 breast cancer cells at low μM concentrations, with minimal toxicity on the non-tumorigenic MCF-10A mammary epithelial cells.

The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.

Compound 9 identified as most active analog with IC50 value of 0.64 μg/mL and SI value of 34.78 against amastigotes, and is several folds more potent than the reference drugs sodium stilbogluconate and paromomycin.

Where, a training set representing the most active lead analogs [12, 13] was selected, energy minimized and submitted to flexible alignment for analyzing the shared spatial arrangement of their pharmacophoric features.

The most active cinnamaldehyde analogs were found to affect the starvation response, biofilm formation, pigment production and protease production in Vibrio spp in vitro, while exhibiting low cytotoxicity.