Sentence examples for most active agents from inspiring English sources

Since the use of combination chemotherapy has been associated with increased response rates compared to single agents (Fossati et al, 1998), a large programme exploring the feasibility and activity of docetaxel, in combination with the most active agents in metastatic breast cancer, was initiated.

The occurrence of these CRs not only confirms the antitumour activity of irinotecan, but ranks irinotecan among the most active agents in this indication.

Meropenem and piperacillin/tazobactam were the most active agents against P. aeruginosa in all the unit types.

Topoisomerase I and II inhibitors and DNA-damaging agents are considered among the most active agents against SCLC.

The most active agents have an inhibitory constant in the mid-nM range and function via a dissociative mechanism of inhibition.

In initial screening and quantitative evaluation, compound 2r was among the most active agents, exhibiting in the same time the lowest toxicity.

Although the taxanes paclitaxel and docetaxel are among the most active agents for the treatment of a wide range of cancers, tumours often develop resistance to these treatments.

A descendant of the union of Agnes and Josceline, Henry de Percy (1273 1314) was one of Edward I's most active agents in the subjugation of Scotland until the success of Robert de Bruce made him withdraw into England.

Amongst the synthesised compounds, 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- isonicotinoyl -pyrazole (2a) and 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- isonicotinoyl -pyrazoleicotinoyl) 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- isonicotinoyl -pyrazoleceptible M. tuberculosis and several INH-resistant strains.

Some of the stuff may be false; and the most active agents may not be named at all, since the files of any apparatchik who reached a certain rank were normally destroyed.So publishing the files, say opponents of that idea, would cause an unwarranted witch-hunt, implicating some innocents and sparing some of the guilty; it would be better simply to renew the jobs ban and carry on as before.

As the RR was only 12%, the present study demonstrates that at relapse, after the most active at present first-line regimen-incorporating all most active agents-the emerging tumor cell clones are possibly resistant to any available further alternative treatment.