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At 3 years follow-up, the net reclassification improvement of GEP over TNM classification was 0.43 (P = 0.001) and 0.38 (P = 0.004) over chromosome 3 status.The GEP assay had a high technical success rate and was the most accurate prognostic marker among all of the factors analyzed.
These results indicate that using SAM method alone is not sufficient to identify the most accurate prognostic gene signature.
The most accurate prognostic stratification is based on cytogenetics, further refined with the analysis of several gene mutations.
The Breslow thickness is considered to be the most accurate prognostic factor for the risk of metastasis in malignant melanoma [ 1].
Uncertainties still remain about which sampling time (at baseline, during treatment, or at the completion of systemic treatment) could provide the most accurate prognostic information.
In patients with diffuse bacterial peritonitis, APACHE II is the most accurate prognostic scoring system as compared with SAPS II and MPI.
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As combinations of microRNAs are likely to provide more accurate prognostic information, the most accurate subset of variables (microRNA-21, -31*, -99, -100, -125b, -138, -147b, -148a, -210, and -376a) was identified using multivariate survival analysis with a forward stepwise variable selection procedure based on the likelihood ratio.
Smilde et al. showed that in patients with relatively preserved renal function, the 6-variable MDRD formula showed the most accurate estimation of GFR, with similar prognostic information compared to real GFR [ 8].
Further studies are warranted to better understand the utility of bedside ultrasound in patients with mild heart failure, and which ultrasound modality provides the most accurate assessment of hemodynamic congestion for both diagnostic and prognostic purposes.
With several ICH related risk-stratification and prognostic models available, identification of the most accurate and reliable grading scale(s) would be of great value to patients, clinicians, and researchers.
The bulk of accumulating data indicates that IMD in the area of most intense neovascularisation in invasive breast cancer is an independent, significant and accurate prognostic marker in predicting poorer survival.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com