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On the other hand, MNS4, the most accurate modification (H resolution) of Cyclops2, gets the average error reduction of 34%, while MNS5 gets only 11%.
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One famous discovery of the Mann's lab is SILAC (stable isotope labelling by amino acids in cell culture), the most accurate proteome quantification method, enabling detection and characterization of proteins via their interactions, modifications and cellular localizations.
The most accurate results are obtained with the Cockroft Gault equation, whereas the most precise formula is the Modification of Diet in Renal Disease (MDRD) study equation.
If LNA modifications amount to a moderate perturbation of a DNA duplex, new parameters are most accurate.
A modification of the expectation-maximization algorithm that yields heteroscedastic marker variances (i.e., RMLV) resulted in the most accurate marker effect estimates.
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