Normal islets and pNETs express both the VEGFR-1 and VEGFR-2 selectively in CD31-positive endothelial cells [10].
In the present study, we demonstrate that several MBs and supratentorial PNETs express the CA isozymes CA II, CA IX and CA XII.
In contrast, pNETs expressed very low or no TIMP-1 (25% positive, n=4, SS=0.25, data not shown).
Most PNETs are indolent but have malignant potential.
Most PNETs are indolent but have malignant potential [1]– [3].
If untreated, most PNETs grow and eventually metastasize to the liver; extensive liver metastasis is the most common cause of death for patients with PNETs [33], [34].
FDG-PET is not usually indicated because most PNETs are negative; however, FDG-PET can ascertain the overall tumor burden in high-grade PNETs [59], [60].
Because most PNETs are indolent, a "wait-and-see" approach has historically predominated.
Most PNETs in MEN1 are benign, but metastasis can occur if the tumors are larger than 2 3 cm [147].
Most importantly, express your regret.
