Sentence examples for most HMCLs express from inspiring English sources

Indeed, most HMCLs express IGF1R/IGF1 but rarely express C-KIT/SCF.

Most HMCL expressed readily detectable levels of all three Bim isoforms EL, L and S (76%).

As all HMCLs express GSK3α and GSK3β (Supplementary Figure S2A and S2B), we assessed whether these phosphorylations were mediated by GSK3.

Of note, although increased mRNA levels of sclerostin were only detected in some samples either from patients (8/20) or HMCLs (1/4), all samples from symptomatic MM with bone disease as well as all HMCLs expressed sclerostin at protein level.

For this purpose, we performed growth curve analyses under low serum conditions on different HMCLs expressing (RPMI, L363 and OPM2) or not expressing (KMS12, KMS28BM and KMS28PE) Maf proteins in the presence or absence of LiCl.

Western blot analysis was performed on extracts prepared from different HMCLs, expressing MAFB (L363 and OPM2) and c-MAF ((RPMI8226, H929, LP-1 and JJN3 KMM1) and from cell lines with no endogenous expression of Maf proteins (KMS12PE (KMS28PE KMS28PE and KMS28BM) as negative controls, using the p-Maf Ab.

BAFF-R expression is absent in most HMCLs, but has been reported to be variably present in primary MMCs, albeit at significantly lower levels than the expression of both BCMA and TACI.

Interestingly, taking all HCMLs together (median LD50=20.5 μM), we found that most HMCLs were efficiently killed by curcumin; we observed that 16 HMCLs were highly sensitive (LD50 < 20.5 μM), and 6 HMCLs exhibited intermediate LD50 values (20.5 μM ≤ LD50 < 32.2 μM); only 7 HMCLs exhibited the highest LD50 values (32,2 < LD50 < 56 μM).

The present data suggest that the G2 control checkpoint induced by DNA damage is functional in most HMCLs.

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