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Post mortem identification of these plaques together with neurofibrillary tangles and neuronal loss is currently the definitive and only fully accepted diagnostic confirmation of AD [5], [6].
Currently, confirmation of a clinical diagnosis of AD still requires post mortem identification of parenchymal amyloid beta (Aβ) deposits and intra-neuronal neurofibrillary tangles composed of abnormally phosphorylated tau protein [ 2- 5] and severe loss of brain tissue [ 6- 8].
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Post-mortem identification of carbon dioxide intoxication might even be more difficult.
While clinical diagnosis is based on symptoms, definite AD diagnosis is based on post-mortem identification of extracellular β-amyloid (Aβ) plaques and intraneuronal neurofibrillary tangles.
Dental evidence for post-mortem identification is often examined on a dissecting table through unavailability of an identification table.
In the biblical account, God wants to insure that "no man" can identify Jezebel, although he may be possibly misinformed about the utility of palm prints and sole impressions in post-mortem identifications.
First, perinatal post-mortem examinations allow for the identification of genetic and obstetric factors that are of relevance to the management of future pregnancies, allowing for appropriate counselling of families.
Ackerman and colleagues [ 31] report the results of post-mortem molecular testing and the identification of a novel mutation in a young woman who died in the ICU after a near-drowning secondary to what turned out to be a form of congenital long-QT syndrome.
The LBC1936 study has revealed that white matter integrity correlates with cognitive performance [ 66, 67], therefore detailed analysis of white matter at post-mortem will aid in the identification of visible abnormalities and hyperintensities observed during in vivo imaging (Fig. 2), which are currently unexplained [ 68, 69].
Diagnosis of TSE infection in animals is currently only achieved by the identification of PrPd in post-mortem or biopsy tissue samples usually of brain.
Post-mortem studies in AD brain allow the identification of long-term synergistic in vivo effects of tau and Aβ in human because, in the majority of AD cases, both pathologies persist in parallel for many years.
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