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For example, EE may cause an increase in striatal and hippocampal levels of brain-derived neurotrophic factor (BDNF; [8]), levels of which are known to be reduced in the striatum and hippocampus of HD mouse models [9] and in the post mortem brains of HD patients [10].
A primate-specific isoform of yet another member of the voltage-gated ether-à-go-go family, KCNH2 (ERG1), is highly expressed in post mortem brains of schizophrenics.
Several studies report protein interaction networks characterizing the molecular disease phenotype in post mortem brains of sporadic AD patients or patients with familial Alzheimer disease [ 54, 55].
Finally, we analyzed published microarray data obtained with post mortem brains of Huntington's disease (HD) patients to investigate the possible involvement of HIPPI in HD pathogenesis.
Early interest in IDPs was spurred by observations that post mortem brains of neurodegenerative disease patients contained high levels of intra- or extra-cellular IDP deposits that were later shown to be representative of the different pathologies.
In normal appearing white matter of post mortem brains of CALD cases, a 39fold excess of C26:0 was found in the phosphatidylcholine fraction compared with white matter tissue of controls [25].
Similar(54)
Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have been reported in serum and post-mortem brains of patients with AD, but its role in progression of AD is unclear.
Past research has found higher levels of amyloid deposits in the post-mortem brains of people who had worrisome cholesterol readings before their death.
The researchers found none of these differences when they compared the post-mortem brains of 20 macaques who got either the highest dose of thimerosal or the most extensive range of vaccines with those of 12 who got the placebo injections.
The post-mortem brains of children with autism who have died have typically shown distinct differences from the brains of normally developing children: in three regions of the brain--the cerebellum, the hippocampus and the amygdala--the brains of children with autism depart significantly from the norm in size and in the density and structure of cells.
Early studies revealed that the levels of neurotransmitter receptors were altered in post-mortem brains of early HD [5], [6], [7], [8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com