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Re-intubation, length of stay and mortality were secondary outcomes.
Among others, 28 days and 6-month mortality were secondary parameters.
Resumption of anticancer therapy in patients who survived the ICU stay and 90-day mortality were secondary endpoints.
Other cancers, vascular disease, side effects and mortality were secondary endpoints.
Development of lung injury (according to consensus criteria for ALI/ARDS) [ 17], duration of mechanical ventilation, and mortality were secondary outcomes.
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Recent criticism of this work, however, questions whether the increased mortality was secondary to the actual usage of CPOE, or whether the manner in which the hospital implemented CPOE was a confounding factor [8].
Thus, it can be debated whether the overall improvement in mortality is secondary to the optimization of management and a less aggressive (or harmful) ventilatory strategy or is merely due to having less severely ill patients admitted to the PICU.
It has been reported that approximately 75%% of all bicycle-related mortality is secondary to head injuries, 85%% of which could have been prevented by wearing a bicycle helmet (The Center for Head Injury Statistics 2014).
It could be argued that this mortality is secondary to withdrawal from the positive effect of BM-containing IgA and CCL28 at a time of life when the immune response is still immature.
Our study suggests that the improvement to unit mortality was secondary to patient selection, rather than a fundamental change in clinical practice within the ICU.
It was then suggested that, in the Leuven trial, difference in observed mortality was secondary to a higher mortality in the control group due to an excessive glucose load.
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