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In-hospital morbidity and mortality were high.
This retrospective analysis of SCID patients in the Netherlands shows that morbidity and mortality were high.
However, both relapse and non-relapse mortality were high, and better tolerable regimens must be developed, particularly for patients with secondary MDS.
Global ICU and in-hospital mortality were high (respectively 59%and7676%) and did not differ between DrotAA-treated and -untreated patients (ICU mortality 62.5% vs. 57%; hospital mortality 75% vs. 77%; both P > 0.05).
13, 14, 16 Using originally proposed cut-points, the negative predictive values (NPV) for ruling out short-term mortality were high (mostly exceeding 90%), whereas ability of the models to correctly predict occurrence of death (positive predictive value; PPV) was substantially lower, in most cases less than 50% (range: 17 57%) (Table 3a).
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Crude rates of 90-day mortality were higher for patients who received colloids (OR 1.845 [1.560; 2.181]).
Both ICU and hospital mortality were higher in patients who received DC than those medically treated.
In multiple logistic regression analysis, the factors which remained significantly associated with patients' mortality were high-grade sputum at the start of treatment (AOR 11.19; 95% CI 2.50, 30.11), presence of lung cavities at the start of the treatment (AOR 7.25; 95% 2.76, 19.07), being alcoholic (AOR 2.54; 95% CI 1.17, 5.51) and being older (AOR 1.03; 95% CI 1.01, 1.06) (Table 5).
Child mortality is high, literacy extremely low.
"Traditionally in all societies, when mortality is high, fertility tends to be high.
Yes, diagnosis is elusive and mortality is high, but if caught early, pancreatic cancer is treatable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com