It is also likely that individual-related factors, such as illnesses, become more important than environmental features in predicting mortality risk when people reach very old age.
However, once fitness was included in the model (model 3) the 22% higher mortality risk did not reach statistical significance (HR=1.22, 95% CI 0.97 to 1.54).
However, uncorrected Cox proportional hazard analysis, censoring patients at last follow-up, suggested a lower mortality risk for patients reaching target.
The effects of total sedentary time on increased mortality risk did not quite reach statistical significance once fitness and covariates were adjusted for (p=0.05).
In addition, an increased mortality risk was observed when patients reached an ScvO2 of at least 70 % with concomitantly high Pv-aCO2 values.
Alcohol-dependent people with reduced alcohol consumption lowered their mortality risk, even if abstinence was not reached.
Although the results of each analysis presented herein demonstrates an increased mortality risk for those with CPB exposure, none of the results reached statistical significance.
We estimate that if the ongoing multicentre RENAL RCT (planned n = 1,500, ClinicalTrials.gov NCT00221013) of high-dose versus standard-dose CRRT demonstrates the expected absolute mortality risk reduction (from 60%to52%2%), the pooled mortality benefit would just reach statistical significance.
Women in non-management positions showed a tendency to have a reduced mortality risk compared with those in management, but this result did not reach statistical significance.
Self-report of mild hypoglycemia also trended toward higher mortality risk compared with no hypoglycemia (1.564 [0.986–2.481]), but this difference failed to reach statistical significance.
