Although the mortality risk may decrease once remission of hypercortisolism is achieved, overall mortality and cardiovascular risk remain elevated in these patients when compared with control populations [ 4, 10].
In adjusted models only, mortality risk became significantly higher once A1C levels exceeded 10.0% (HR 1.21 [95% CI 1.01 1.45]).
Apparently, diabetes is a risk factor only for the development of complications, but once acquired, the mortality risk is equal to or perhaps even lower than that of nondiabetic patients.
The effects of total sedentary time on increased mortality risk did not quite reach statistical significance once fitness and covariates were adjusted for (p=0.05).
Because some patients had multiple codes for infections, we devised a hierarchy based on associated mortality risk to ensure that patients were counted only once and were classified into the highest mortality risk group.
However, once adjusted by APACHE II mortality risk, using a multivariate logistic regression analysis, with the exception of the overall mortality, there was no differences between the two periods in the three clinical areas studied.
Findings reveal that increased total sedentary time is related to higher mortality risk from all causes when fitness is not accounted for; however, once controlling for fitness the sedentary behaviour mortality relationship is reduced.
Once fitness was added into the model, then increased mortality risk from prolonged sedentary time was 22%.
Once high-risk children can be identified, innovative solutions to reduce their mortality risk must be sought.
However, once fitness was included in the model (model 3) the 22% higher mortality risk did not reach statistical significance (HR=1.22, 95% CI 0.97 to 1.54).
