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Imagine that the mortality risk does not increase with age.
A thresholdlike model indicating that the bladder cancer mortality risk does not increase with exposure levels < 150 μg/L is consistent with other epidemiologic data.
Furthermore, in contrast with previous observations (22), the association between metabolic syndrome and mortality risk does not appear to be related to the number of metabolic syndrome factors one displays.
The authors' conclusion that baseline mortality risk does not impact the potential for benefit or harm derives primarily from the observation that the three clinical trials showing a statistically significant beneficial treatment effect have placebo mortality rates ranging from 31%to61%1%, whereas an apparent lack of efficacy in other trials occurs across a spectrum of baseline mortality risk.
Our results suggest that there are important sex and age differences in the way the different metabolic syndrome combinations relate to mortality risk; however, the association between the various metabolic syndrome combinations and mortality risk does not appear to be related to their prevalence.
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AF related mortality risk did not differ between patients with and without RA.
In contrast, a subsequent trial suggested that patients with lower mortality risk did not benefit [ 10].
The comorbidity-based mortality risk did not predict HRQoL in stroke patients still living at home after 2.5 years.
The effects of total sedentary time on increased mortality risk did not quite reach statistical significance once fitness and covariates were adjusted for (p=0.05).
However, these analyses of ethnic group and maternal and perinatal mortality risk did not account for the combined effect of BMI.
However, once fitness was included in the model (model 3) the 22% higher mortality risk did not reach statistical significance (HR=1.22, 95% CI 0.97 to 1.54).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com