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The classic demographic transition starts with mortality reduction, followed after a time by reduced fertility.
The largest contribution to deaths prevented by increased uptake of treatment came from statin treatment for hyperlipidaemia (approximately 13% of the total mortality reduction), followed by secondary prevention after myocardial infarction (9%) and management of chronic stable coronary artery disease (7%) (table 2).
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In countries at the second stage of demographic transition, mortality reduction is followed by fertility decline [ 1].
The reduction followed three decades of increases.
The fecal occult blood test (FOBT) and sigmoidoscopy are the only screening methods with a documented mortality reduction over a follow-up period of 10 years.
This large, prospective Taiwanese cohort undergoing population-based FIT screening for CRC had the statistical power to demonstrate a significant CRC mortality reduction, although the follow-up time was short.
The large cohort data presented herein provide the statistical power for demonstrating a significant CRC mortality reduction even though the follow-up time was short.
The explanation for this lower than expected mortality reduction, predicted by MISCAN, is as follows.
Prospective assessment of mortality reduction requires a very lengthy follow-up and a large study population, which may not be feasible.
Nondiabetic but not diabetic subjects had a significant all-cause, CVD, and CHD mortality reduction during the 33-year follow-up whereas diabetic men but not women had a significant average reduction of CVD and especially CHD mortality rates.
A total of 160 921 women had been randomised, 53 914 to the intervention arm and 107 007 to the control arm; the probability of demonstrating a 20% breast cancer mortality reduction at 10 years of follow-up (under the same assumptions as above) is thus reduced to 73%.
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