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We found that, for a population limited by density-dependent effects, delaying the time of death until after the density-dependent mortality phase has a strongly beneficial effect on program effectiveness (Fig. 1).
However, unless the transgene system is completely stage-specific, transgenic individuals may be weakened by the effect of the system before they are killed, and then might not be fully competitive with wild type during the density-dependent mortality phase.
We found that, for a population limited by density-dependent effects, delaying the time of death until after the density-dependent mortality phase would have a beneficial effect on program effectiveness, irrespective of assumptions about mass-release ratios or density-dependence parameters, though the effect is stronger for stronger density-dependence (Fig. 1).
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The further analyses were strictly performed according to the defined phases by the observed nadirs of mortality rate (phase I: Day 1 until Day 5, phase II: Day 6 until Day 15, phase III: Day 16 until the end of the observation period at Day 150).
(3) Relationships between BGd and SOFA score, mortality: (E phase) group AH had the tendency of higher mortality as compared with group AL (100%, n = 3 vs 50%, n = 8); (L phase) group BH had the tendency of higher SOFA score and mortality as compared with group BL (8.0 ± 6.7, 80%, n = 5 vs 6.7 ± 5.7, 38%, n = 37).
On the other hand, correlated selection on traits influencing phenotypes during the high-mortality oceanic phase, or perhaps during spawning, is a plausible mechanism.
The late phase mortality, length of stays and complications such as PSMVT were all significantly higher in the IPN group.
The late phase mortality and hospitalisation length of stay were significantly higher in the IPN group (14.3 vs 3.6%, p = 0.01 and 65.5 vs 15 days, p < 0.001, respectively).
The outcomes in term of late phase mortality, length of stay and complications (i.e. haemorrhage, perforation of visceral organ and mesenteric ischemia) are all strongly associated with IPN.
6 Morbidity and mortality in this phase are mainly due to heart failure, sudden death, and pulmonary or cerebral embolisms.
In the L phase, mortality was not significantly different between the groups with higher BGsd and those with lower BGsd at any point.
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