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Moreover, therapeutic administration of m27f completely prevented infection-related mortality of mice challenged with a lethal dose of HSV-2.
The mortality of mice and E. coli in fecal shedding of control and rOmpF immunized mice was recorded daily for 7 days.
Prevention of desiccation is much more important in open surgery than in laparoscopic surgery considering the 100% mortality of mice when exposed to dry CO2 for 60 min.
The mortality of mice challenged with lethal dose of influenza virus was significantly reduced by intranasal delivery of murine IFN-β and inactivated influenza vaccine (Cao et al., 1992).
For instance, as demonstrated by Hollenberg [22], the mortality of mice 48 h after cecal ligation and puncture was close to 100% without resuscitation, whereas fluids and antibiotic therapy resulted in 45% survival, a value close to the clinical setting.
(A) Weight changes of mice; (B) Mortality of mice; (C) Virus titers of the mouse lungs: five-week-old SPF BALB/c mice (seventeen mice/group) were inoculated intranasally with 106 EID50 of each virus and three mice were euthanized on 3, 5 and 7 days post-infection and lung tissues were collected for virus titration in eggs.
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The anti-hepatitis assay showed that the petroleum ether and ethyl acetate extracts of D. heterophyllum significantly prolonged the mean survival times and reduced the mortality of mouse hepatitis model induced by concanavalin A (ConA).
With regard to the anticoagulant effect dependency, Wildhagen et al. [25] demonstrated the fractioned non-anticoagulant heparin suppresses histone cytotoxicity and reduces the mortality of mouse models of sepsis.
According to the killing efficiency estimated in spore-killing experiments (approximately 25%, Fig. 4B), around 7.5×106 CFU spores should be remained viable, and theoretically the mortality of mouse should have reached up to 100% (Fig. 5A, 7.5×106 CFU groups).
T. gondii isolate was considered as virulent if 100% mortality of mouse was observed within four weeks of infection [ 33].
Injection dose of GO at 0.1 and 0.25 mg per mouse did not cause mortality of exposed mice, and showed no obvious clinical toxic signs, and the body weight of treated mice accordingly increased with the raise time increasing.
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