In the analysis of long term changes in infection rates or mortality rates, we must consider whether changes in the population, advances in laboratory diagnostic techniques, changes in exposure to risk factors, microbial culture and other factors lead to increased or decreased rates.
Given the high survivorship of BC [ 6, 7] and how glucose and lipids are linked to CV mortality [ 8, 9], one must consider the possibility of competing risks.
Sometimes you find rare things that really should belong to you, and you must consider your own mortality.
A reduction in myocardial infarctions without a reduction in mortality must be considered cautiously.
Thus, prevention of post-transplant malignancy-related morbidity and mortality must be considered a main end-point in solid organ transplant programmes.
Although TNF antagonist therapy is generally well tolerated by patients with IBD, a unique spectrum of safety issues related to blocking TNF, including life-threatening and opportunistic infection, malignancy, and mortality, must be considered.
In other words, one must consider the possible complications and mortality of surgery versus the probable remission of diabetes and decrease in lifelong diabetes-related morbidity and mortality.
Clearly further study is warranted, but one must consider that the time-honored endpoint of mortality is not well suited to assess the interventions targeting acid base balance.
More importantly, one must consider why a subgroup analysis of 90-day mortality, a secondary outcome, was performed rather than a subgroup analysis of the primary outcome, 28-day mortality.
