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Earlier this year, researchers found that intentional weight loss had no effect on mortality in overweight diabetics followed for 19 years.
Williamson DF, Pamuk E, Thun M, Flanders D, Byers T, Health C. Prospective study of intentional weight loss and mortality in overweight white men aged 40 64 years.
The Look AHEAD trial was a multi-center, randomized controlled trial, to determine whether weight loss reduces cardiovascular morbidity and mortality in overweight individuals with type 2 diabetes.
And also showed that metformin was efficacious against macrovascular complications and overall mortality in overweight patients [ 3].
In addition, our findings did not confirm increased mortality in overweight or obese critically ill patients without DM.
APOE*2 was not associated with a lower risk of all-cause mortality in overweight or obese persons.
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A recent analysis of 5,766 patients from the German Trauma Registry also showed a significant correlation between BMI and mortality in both overweight and underweight patients [ 19].
We carried out categorical, linear, and non-linear dose response meta-analyses to examine the magnitude and the shape of the associations for total and cause-specific mortality in underweight, overweight, and obese women by time periods before and after diagnosis that is important in relation to the population-at-risk and breast cancer survivors.
Look AHEAD is a multicenter, randomized clinical trial examining the long-term effects of lifestyle interventions on cardiovascular morbidity and mortality in 5,145 overweight or obese participants with type 2 diabetes who were randomly assigned to intensive lifestyle intervention (ILI) or to usual care, referred to as diabetes support and education (DSE) (8, 9).
A systematic review of 40 cohort studies with 250,152 patients found significantly lower risks for total mortality (RR 0.87) and cardiovascular mortality (RR 0.88) in overweight patients (3).
Lowest 1-year mortality was observed in overweight patients and lowest overall mortality was observed in obese patients, and altogether high BMI showed a protective effect against mortality, even after adjustment (Table 2).
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