Recently, a mortality gene expression signature was identified in C. gigas hemocytes of oysters that died in the field during summer mortality events in USA [ 34].
In mice, mast cells can degrade NT and reduce NT-induced hypotension and CLP-associated mortality, and optimal expression of these effects requires mast cell expression of neurotensin receptor 1 and neurolysin.
For larvae exposed in the experiment designed for analysis of gene expression, mortality was significantly higher in 5%THF C600 than in 5% THF water, and both treatments had significantly higher mortality than 2.5%THF C600, 2.5% THF water, and C60 water, which did not differ significantly from the control.
Depletion of these cells before a sublethal infection with 1918 HA/NA Tx/91 virus was shown to result in increased virus growth, mortality and decreased expression of cytokines and chemokines in mice [67].
The mortality and gene expression patterns could have been influenced by the proximity to final maturation and processes associated with natural senescence.
The precision of the transcriptional response between T4 treatments indicates that axolotls are surprisingly tolerant to T4 levels that dramatically affect anuran mortality and gene expression.
The predominant clone seemed to be associated with increased mortality and ESBL expression but not with the presence of the integron.
Treatment of infected zebrafish with a known anti-influenza compound, Zanamivir, reduced mortality and the expression of a fluorescent viral gene product, demonstrating the validity of this model to screen for potential antiviral drugs.
For disease mortality, the gene expression models also outperform the model based on clinical parameters (model A, median C-index of 0.59), though this is not the case for disease recurrence (median C-index of 0.58 for clinical model).
The association between all-cause mortality and biomarker expression was assessed using Kaplan Meier curves and the log-rank test, using the 'minimum P-value approach' with adjusted P-values and a significance level of 0.05 (Faraggi and Simon, 1996).
