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These findings are consistent with a report from Rochester, Minnesota, which showed that between 1970 and 1994 mortality declined in diabetic subjects, although this decline was smaller than the mortality decrease observed in the nondiabetic population (19).
A study carried out in a neighbouring area attributed an increased gastric cancer risk to consumption of a "traditional" diet reach in red and conserved meat [ 29, 30]; a different attention to diet and health could explain the earlier mortality decrease observed among females.
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The five-fold decrease observed in perinatal mortality among newborns after the implementation of PS exceeded that reported for the mentioned Helsinki trial [ 3].
A primary statistical inference illustrated in Figure 6 of our article (Pope et al. 2007) is that similar and consistent (not significantly different) mortality decreases were observed across all four Southwest states.
Several models used the decreased mortality observed in clinical trials (EBCTCG 1998a, 1998b) as model inputs to estimate the effect of therapies on mortality.
Many reports have shown that the use of antimicrobial guidelines was associated with improved appropriate antibiotic use, decreased duration of AT, reduced antibiotic costs and could decrease mortality, as observed in hospital-acquired pneumonia [ 37, 38].
Our in-ICU mortality remains lower (15.5 to 15.6%) whereas observed mortality decreased (22.37 to 19.88%; P 0.001).
Thus, we find it unlikely that unmeasured or unknown confounders could explain mortality decreases of the magnitude observed.
The observed mortality decreases in these studies ranged between 1% and 9% annually (Moss et al, 2012).
As shown in Table 4, observed mortality decreased also for women with high and with low education (High: 25.596 to 16.520; Low: 46.255 to 42.153).
Recently, improved bacterial clearance and decreased mortality were observed in PD-1 knockout mice [ 1].
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