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Data on mortality at fixed intervals were extracted from the studies and a table was populated (see Table 1).
Several publications have previously shown why mortality at fixed time intervals is a more appropriate measure in outcomes evaluation.
The second review, which excluded articles that did not examine CDI mortality at fixed intervals, resulted in a further exclusion of 23 articles.
A second review of the articles was undertaken, and this step excluded articles that did not examine mortality at fixed intervals, for example, 30 or 90 days.
The inclusion of studies that documented mortality at fixed intervals was chosen in an attempt to assist the pooling of data during data analysis.
In three studies, the investigators reported readmission to the ICU and hospital mortality at fixed time periods following patient discharge from the ICU (48 hours [ 26], 7 days [ 44] and 2 weeks [ 36]).
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The model was reduced to two parameters for binary responses (immobilization and mortality) by fixing the upper limit d at 1.
In all our simulations, the mortality parameter m was fixed at 0.2 and the maximal reproductive rate cmax at 5.0.
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