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The mortality analysis did not include patients with pre-existing renal disease.
The primary mortality analysis did not reveal a significant difference in survival between the treatment groups.
The trial by Wunderink et al 10 was the only one that did not provide 28-day mortality (only 60-day mortality)—its removal from the mortality analysis did not change the original findings (RD=0.006 955% CI −0.019 to 0.031); p=0.649; I=21%).
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Consequently, proportionate mortality analysis does not provide a true estimate of the risk.
Regarding the risk for overall or cardiovascular mortality Cox regression analysis did not show interactive effects between GSTM1 and GSTA1 polymorphisms.
Since we only corrected nationwide reported mortality rates, our analysis did not consider a possible skewed distribution of German repatriates and Jewish emigrants in Russia.
Among other findings, Zeka and Schwartz (2004) found an association between CO and daily mortality when traditional analysis did not, suggesting that a high degree of measurement error due to spatial heterogeneity of CO concentrations may be contributing to the difference in findings.
The crude mortality analysis, however, did not show a statistically significant difference between groups (11/34 polymyxin group vs. 16/30 conventional group, odds ratio = 2.39 (95% confidence interval = 0.87 to 6.60), P = 0.09).
In the parallel-group trials that provided these data, all patients were analyzed according to the group to which they were initially assigned, and withdrawal of randomized patients from the mortality analysis either did not occur [ 26, 27] or comprised ≤5% of randomized patients [ 21, 23, 30].
Unlike the mortality analyses, the incidence analysis did not show a statistically significant effect for external dose after adjusting for internal liver dose, although the estimates from this study and the mortality data were nearly identical (Table 4).
With regard to mortality, the results of regression analysis did not differ between the cohort of patients whose APACHE II scores were available and the cohort of patients whose APACHE II scores were not.
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