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Mortality analyses indicated that the primary effect of the C32 mutation was a reduction of initial mortality rate (Figures 2C and 2D).
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Although pooling of study drugs may have overlooked variation in associations with mortality across classes, subgroup analyses indicated statistically significant associations (and dose-response effects) between mortality and all three classes of study drug.
Both analyses indicated that leaf mortality risk increased monotonically with leaf age.
Prespecified as-treated analyses indicated a potential mortality benefit in patients with GCS<9 receiving physician intervention with the number needed to treat to prevent one fatality being six in this group.
However, the implications of using the technique appeared modest in the analyses, as all analyses indicated a lower mortality among patients diagnosed in 2010 patients compared with patients diagnosed in 2003 patients independently on how the available covariates were included in the multivariable analyses (data not shown).
Further analyses indicated that the likelihood of mortality at day 8 and day 30 was lower for subjects with lower APACHE II scores.
Sensitivity analyses indicated that the quality of life, annual mortality rate, and the effectiveness of AEDs in improving survival were the most influential factors in the model.
Stratified analyses indicated that reductions in all-cause and CVD mortality were observed relatively uniformly across the population (Table 4).
Further analyses indicated that the GRS were not significantly associated with CVD-mortality (Table 4), nor were any significant associations observed between the GRS and history of prior CVD or history of prior MI (0.06 < p < 0.87).
*Interaction analyses indicated that high age significantly increased the effect of type of bacterium on hospital mortality (results not shown).
These analyses indicated that, by chance, older and sicker patients were being randomized to the drugs with the higher mortality rates.
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