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All demonstrate a clear need for these computational and morphometric approaches in order to increase the consistency, objectivity, and throughput of plant morphological studies.
The approach we have used has previously been shown to reveal regional thalamic alterations that are consistent with focal alterations in thalamocortical connectivity [Hughes et al., 2012], and also corroborate the observation of thalamic changes using other morphometric approaches in patients with idiopathic generalized epilepsy [Kim et al., 2013; Saini et al., 2013].
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This effort led to the rise of voxel-based morphometric approaches and statistical mapping approaches in general.
These findings illustrate the potential confounds inherent in morphometric approaches that ignore or attempt to minimize inter-individual variations in sulcal and gyral anatomy and underscore the need to consider this variability when attempting to understand disease processes or characterize brain structure function relationships.
In particular, we applied sophisticated morphometric approaches to investigate regional alterations in cortical thickness and the surface shape of the mesial temporal lobe, thalamus, and basal ganglia in patients relative to healthy controls, and in patients experiencing persistent postoperative seizures relative to those rendered seizure free.
Structural relationships were defined using ultrastructural and morphometric approaches while transparency was analyzed using in vivo confocal microscopy.
However, these morphometric approaches cannot yield whole-lung information in vivo.
The past two decades have witnessed a surge of interest in applying geometric morphometric approaches to understand how body shape changes and how such a change is associated with allometry during ontogeny [21] [23].
For the study of subtle morphological differences in overall body shape, landmark-based morphometric approaches are better able to visualize and quantify changes among populations than traditional methods (Adams et al., 2004; Maderbacher et al., 2008).
Limitations of this study include variability in outlining the hippocampus, which is common to all morphometric approaches based on manual tracing.
MATERIALS AND METHODS:Geometric morphometric approaches were used to quantify the shape of the bones.
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