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Ankylosing spondylitis (AS) is associated with an increased incidence of vertebral fractures (VFs); however the actual incidence and predictors of morphometric VFs are unknown.
Although many VFs are not diagnosed because the majority of patients suffer only mild back pain, morphometric VFs are associated with a poor quality of life and impaired physical function [ 11].
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The incidence of morphometric VFs was 4.7% at 2 years and 13.6% at 4 years.
The risk of morphometric VFs was about three times higher than that in the general population.
In this study, using radiographs, the incidence of morphometric VFs was estimated to be 4.7% at 2 years and 13.6% at 4 years.
Nevertheless, criteria for patient selection were variable in these studies (consecutive patients or patients selected on the basis of disease activity, occiput to wall distance (OWD), sex or age, and including clinical VFs or systematic evaluated morphometric VFs), as were the criteria for VF diagnosis (variable thresholds of vertebral height loss) [ 10– 10].
Because post-fracture wedging of the vertebrae can contribute to hyperkyphosis and neurologic complications [ 12], it is important to identify the predictors of morphometric VFs if we are to effectively manage AS patients.
The age-specific specific standardized prevalence ratio of morphometric VFs in AS was 3.3 (95% CI 2.1 4.5).
VFs were observed in 41/275 patients (15%).
The prevalence of VFs is high in AS; however, the diagnosis of VFs is difficult.
The difference between untreated VFs and normal VFs was significant (p < 0.001).
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