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Exact(8)
The number of postembryonically born neurons in the ventral cord decreased and their axon morphology was abnormal.
However, neither cellularity nor morphology was abnormal in thymi of adult PKBα−/− mice nor in PKBβ−/− and PKBγ−/− neonatal thymi.
Fracture callus morphology was abnormal in the rofecoxib-treated rabbits and torsional mechanical testing showed that fracture healing was impaired.
The optic nerve head morphology was abnormal with significantly decreased optic disk area, retinal nerve fiber layer thickness, cup area and cup depth in FRMD7 patients (P < 0.0001).
Attempts to collect embryos at E12.5 yielded only one double mutant in which limb morphology was abnormal, but retarded development meant digit number could not be reliably ascertained.
After 72 hr, OPA1 levels in liver mitochondria were reduced by ∼50%, cristae morphology was abnormal, RCS were reduced, and glutamate/malate RCR was impaired.
Similar(51)
Neuronal numbers and cellular morphology are abnormal in several brain regions, including the hippocampus and cerebellum.
It is also well known that the brain morphology is abnormal in schizophrenia.
In both cases, vulval cells invaginate and form finger-like structures, but the overall morphology is abnormal.
For example, mutants in which pharyngeal elongation and hence muscle morphology is abnormal (such as sma-1 and let-502 ) may result in gland hypertrophy through loss of one regulatory mechanism, while mutants affecting pharyngeal muscle ultrastructure and/or function (such as tnt-4 and unc-89 ) may have a different effect on gland growth.
Furthermore, mitochondrial morphology was highly abnormal in A-KO BAT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com