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Characteristic, although not definitive, endothelial features include morphology, vWF expression, strong uptake of DiI-Ac-LDL and staining with UEA-1 lectins [ 26].
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The trend for vWF expression was reverse.
Other frequently used platelet function tests such as PFA-100 are influenced by platelet count and circulating von Willenbrandt factor (vWF), and hypothermia itself reduces platelet count and increases vWF expression.
Moreover, in vivo experiments illustrated that DHA can significantly inhibit migration and invasion of ovarian cancer cell by reducing vWF expression and macrophage infiltration [21].
In MSC-treated rats, BSCB leakage was reduced, vWF expression was increased and locomotor function improved beginning 1 week post-MSC infusion, i.e., 2 weeks post-SCI.
Similarly, no vWF expression and high CD34 expression were observed at gene level (Fig. 2B).
As expected, the phenotype and function (VWF expression) of tumor endothelial cells in these cancers were essentially abnormal (Fig. 6).
vWF expression was recorded as 0, 10 or >10 Weibel Palade bodies (WPB) per cell, with high level expression defined as >10 WBP per cell.
For confocal microscopy, FVIII and vWF expression levels per cell were defined semi-quantitatively by examination of at least five separate high power fields.
Finally, TVECs in human native cancers such as cervical and breast cancers were found to be defective in phenotype and function (VWF expression).
Laser confocal microscopy showed that sorafenib inhibited vWF expression and GdCl3 reduced CD68 staining.
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