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We examined the morphology of peripheral red blood cells as a proxy for iron deficiency (hypochromic microcytic cells) and vitamin B-12 and folate deficiency (macrocytic cells) [18].
Dystroglycan, β1 and β4 integrin subunits have been shown to be important for different aspects of myelination and morphology of peripheral nerves, as revealed by conditional disruption of their genes in Schwann cells [18] [20].
To what degree sexually dimorphic vocal behavior arises from differences in central neural control and differences in the functional morphology of peripheral organs is an important question for understanding the evolution of vocal behavior.
Next, we investigated the morphology of peripheral nerves.
Consistent with the immature morphology of peripheral erythrocytes and revealing a defect in red blood cell maturation, BM pro-erythroblasts were increased and the relative percentage of more mature orthochromatophilic erythroblasts and reticulocytes was significantly reduced in AE expressing animals (I and IV, Fig 1F, Supporting Information Fig S5A).
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E. coli L-form colonies appeared in 48 72 hrs, were mucoid, and exhibited typical "fried egg" morphology, consisting of peripheral growth on the surface of the agar with a dense center embedded into the agar (Fig. 1A).
On the other hand, when α-syn induced both neuronal pathology and cell death, there was a delayed increase in microglia cell numbers, which correlated with long-lasting CD68 expression and a morphology reminiscent of peripheral macrophages.
Cytokine secretion and cell morphology of human peripheral blood monocytes allowed to differentiate on the different matrices were analyzed.
In the morphants no Prp2 activity could be detected and the Zn12 antibody visualized altered trigeminal ganglion morphology and reduced number of peripheral neurons in the head (Fig. 3C).
Concomitantly, specific changes of peripheral nerve morphology, nerve structure, and myelin proteins (P0 and PMP22) expression were observed.
Furthermore, inspection of peripheral blood morphology documented atypical red blood cells characterized by a polychromatic, aniso- and poikilocytotic phenotype (Fig 1D, arrowheads).
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