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Representative morphology of lung sections from WT, βENaC-Tg, MMP12−/−, and βENaC-Tg/MMP12−/− mice demonstrates that increased MMP12 activity on BAL macrophages also contributes to structural lung damage (right lower panels).
Moreover, the measurement of alveoli showed the ability of PCI to observe the morphology of lung.
Although the overall cell morphology of lung epithelial cells was retained, E-cadherin-containing cell junctions were less focused and more dispersed.
Therefore, this technique has the potential use in disease diagnosis, such as asthma, chronic bronchitis and emphysema, which are associated with the size or morphology of lung airways.
The morphology of lung tumors was similar to that of mammary tumors.
This is in accordance with two recent studies with small animals (rat and rabbit) [ 19, 52], which failed to demonstrate regional differences in the morphology of lung injury in either of the body positions through semiquantitative or subjective evaluation, respectively.
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As a first step we examined the morphology of lungs from mice lacking both Rab27 isoforms (DKO).
Many lung diseases alter the morphology of the lung tissue [1] [6].
Although constitutive Notch signaling altered the overall morphology of the lung and guts, more severely than in the tri-transgenic mice, many parts of the lung epithelium showed extensive SSEA-1 immunoreactivity (Fig. 5G).
In conclusion, our novel modified method, which avoids the disadvantages of generating artifacts, fulfills the requirement of preserving the clear, natural morphology of the lung making it suitable and worthy of recommendation for toxicological studies in a good laboratory practice (GLP) lab.
Recently, UCH L1 was shown to enhance the invasive capacity, cell adhesion and morphology of a lung cancer cell line via the AKT pathway, where phosphorylated AKT is reduced in the absence of UCH L1, although total AKT levels are not affected [11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com