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Several factors (e.g., structure of surfactants and solute, aggregation number, morphology of aggregates, ionic force, and temperature) influence the capacity of QACs to be used as new drug delivery systems.
We applied Atomic Force Microscopy (AFM) techniques to follow peptide peptide interactions at the single molecule level, to visualize the morphology of aggregates formed by both constructs, thioflavin T (ThT) fluorescence to follow the aggregation kinetics, and circular dichroism (CD) spectroscopy to characterize the secondary structure of the constructs.
Iron and carbon doped nanostructured titanium dioxide with different morphology of aggregates was synthesized using the developed precursor technique.
The moment of inertia tensor is a quantity that characterizes the morphology of aggregates of particles.
The morphology of aggregates formed by crude oil drops and particles was strongly related to the contact angle (θwo) at the water oil particle interfaces.
Systematic characterizations including TEM, SEM, BET analysis, XRD, and r-PL were performed for the ZnO aggregates annealed at various temperatures, and the results revealed that the morphology of aggregates, crystal size of primary particle, crystallinity, specific surface areas and the surface states largely depends on the annealing temperature.
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When the micelles were prepared in water/acetone (v/v=2/3) mixture and cast them on a glass slide at different temperatures (from 50 up to 200 °C), the transformation of the morphologies of aggregates, from needle-like solid to microcubic particles, was observed using SEM.
Indeed, different strains of mouse prions causing different morphologies of aggregates and targeting different brain regions activate different combinations of chaperones (Asuni et al., 2013).
Although there is similarity in the morphologies of aggregates identified in vitro and in vivo, it is important to note that the crowded cellular environment affects Htt aggregate species and the aggregation pathway itself in vivo.
In vivo and in vitro studies have shown that aggregation kinetics, toxicity, and morphology of Aβ aggregates are perturbed in the presence of Zn2+.
As aggregation proceeds, these differences in the morphology of Josephin aggregates formed in the absence and in the presence of Ub are consistently observed, as shown by EM micrographs obtained after 6 d at 37°C (Fig. 4 C).
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